Chai Discovery, a biotech startup backed by OpenAI, has introduced Chai-2, a multimodal generative AI model that achieves fully de novo antibody design with a hit rate of approximately 16%, representing a 100-fold improvement over previous methods. Chai-2 can design, synthesize, and characterize antibodies in under two weeks, a process that traditionally takes months to years and requires substantial investment. The model has demonstrated success across 52 diverse targets with fewer than 20 AI-designed candidates per target, significantly accelerating and reducing the cost of drug discovery. Concurrently, researchers at Stanford University and the Chan Zuckerberg Biohub have developed a virtual lab composed of autonomous AI agents capable of designing hypotheses, debating ideas, and conducting biomedical experiments. This virtual lab has rapidly generated COVID-19 nanobody candidates within days, showcasing the potential for AI-driven continuous scientific discovery. These advancements highlight a shift toward AI-powered platforms that can expedite biomedical research and precision medicine development.
👨🔬 BRILLIANT. Stanford and the Chan Zuckerberg Biohub just developed a “virtual lab” of AI scientists that design, debate, and test biomedical discoveries — already generating COVID-19 nanobody candidates in days. 🚀 The setup now gives small labs instant interdisciplinary https://t.co/xyL5gKMGfG
Can confirm at least two massive AI-assisted discoveries are on their way to being published ✍️ Neither was massive compute but 🧠 + 🤖 working together with generalist models. This is the biggest unlock versus brute force - we are already smart just need a bit of help 💪🏽🦾
Stanford & @czbiohub researchers created a team of AI agents to mirror @james_y_zou's lab. New Nature paper on their open source Virtual Lab & AI-human research collab incl an LLM principal investigator: Virtual Lab applied to design nanobody binders to recent Covid variants 1/n https://t.co/rWgVbF1CRG