Recent research highlights the role of hormonal factors in treatment-resistant mental health conditions, suggesting that hormone-related therapies may offer promising alternatives to traditional antidepressants and anti-anxiety medications, which have seen increased prescriptions in wealthy countries but do not work for everyone. Despite evidence that hormone-replacement therapy can alleviate symptoms of mental disorders, awareness among patients and diagnosis by doctors remain limited. Additionally, attention-deficit/hyperactivity disorder (ADHD) diagnoses are rising, particularly among adults over 44 years old, with recognition growing that ADHD is as common in women as in men. Studies also link premenstrual disorders to higher cardiovascular risks, underscoring the need for greater awareness of long-term consequences. These findings point to a broader understanding of neurodevelopmental and hormonal influences on mental health, prompting calls for improved diagnosis and treatment approaches.