Dene-Yeniseian (language family that includes both Na-Dene and Yeniseian languages)
Austro-Tai (language family that includes both Austronesian and Kra-Dai languages)
Italo-Celtic (an IE subfamily that includes both Latin and a Celtic language, but no languages from other major extant IE families)
Je-Tupi-Carib (language family that includes both Je, Tupi and Carib languages)
Pontic (language family that includes both Indo-European and Northwest Caucasian languages)
Paleo-Balkan (an IE subfamily that includes all of: Albanian, Ilyrian, Daco-Thracian, Hellenic, Phrygian. Can also include Armenian, but no languages from other major extant IE families)
Uralo-Siberian (language family that includes Uralic, Yukaghir and Eskaleut)
Altaic (or any other language family containing both Turkic, Tungusic and Mongolic languages)
Indo-Uralic (language family that includes both Indo-European and Uralic languages)
Proto-World (all known languages in the world are proven to belong to the same macrofamily)