Nike co-founder Phil Knight and his wife, Penny, are giving $2 billion to Oregon Health & Science University’s Knight Cancer Institute, marking the largest known single donation to a U.S. university or academic health institution. OHSU said the gift will accelerate early-stage cancer detection, expand patient access to clinical trials and strengthen support services ranging from nutrition to financial counseling. The funding will underpin work led by cancer researcher Dr. Brian Druker, with whom the Knights previously partnered a decade ago in a $500 million fundraising challenge for the institute. The record-setting pledge underscores the couple’s growing philanthropic profile at a time when public funding for higher education and medical research faces pressure. Forbes estimates Phil Knight’s net worth at about $35 billion; the couple’s lifetime giving already exceeds $3.6 billion.