The Environmental Protection Agency (EPA) is intensifying its focus on chemical safety, particularly concerning per- and polyfluoroalkyl substances (PFAS). Recent developments include a petition from three state agencies advocating for the addition of four PFAS to the list of hazardous air pollutants, citing their toxicity and air transport risks. Additionally, the EPA has designated five widely used chemicals as 'high priority' under the Toxic Substances Control Act (TSCA), indicating potential future restrictions on their use and products containing them. In related legal news, the D.C. Circuit upheld the dismissal of a proposed class action against the Department of Health and Human Services (HHS) regarding a shortage of home health aides, while the Third Circuit dismissed Chemours' appeal concerning the EPA's hazardous air limits. The regulatory landscape is evolving as manufacturers respond to ongoing litigation related to PFAS and other chemicals.