Bitcoin balances on cryptocurrency exchanges have reached historic lows, signaling a potential supply shock and increased volatility. On-chain data shows a rapid depletion of available Bitcoin inventory, with the 30-day moving average of Bitcoin on exchanges hitting record lows. This reduction in supply is attributed to long-term holders, or 'HODLers,' who are refraining from selling, tightening the available supply. Analysts, including Tom Lee of Fundstrat, predict that Bitcoin's price could surpass $100,000 by the end of the year, with some projecting even higher targets, such as $250,000, in the coming years. Market conditions and historical trends, such as Bitcoin's halving cycles, are cited as key factors driving these optimistic forecasts.