The San Francisco 49ers are facing challenges in their wide receiver and defensive line rosters as the 2025 NFL season approaches. Rookie wide receiver Jordan Watkins suffered a high ankle sprain on August 9, 2025, which was diagnosed after he reported soreness the following day. Head coach Kyle Shanahan confirmed Watkins will be sidelined for approximately one month. This injury adds to the team's receiving corps difficulties, with Brandon Aiyuk expected to return around Week 6, Demarcus Robinson facing a suspension, and Jauan Jennings dealing with a calf issue. The team is looking to the return of Jacob Cowing to help bolster the wide receiver group. On the defensive side, the 49ers made roster adjustments on August 15, 2025, signing defensive lineman Shakel Brown, who was with the team last season, to address injuries on the defensive line, particularly with CJ West likely unavailable for the upcoming game. To make room for Brown, the team released tight end Ross Dwelley, though there is speculation he may return soon as the tight end position remains healthy while defensive line depth is a concern.