Trey Lance made his return to Levi's Stadium on August 23, 2025, starting for the Los Angeles Chargers against his former team, the San Francisco 49ers, in the preseason finale. The Chargers, coached by Jim Harbaugh, faced the 49ers in a closely contested game that ended with a 30-23 victory for San Francisco. Lance, who was the 49ers' former No. 3 overall pick and part of Kyle Shanahan's quarterback rotation, struggled at times, including a notable third-down overthrow. Despite the defeat, Lance expressed respect for Harbaugh, calling him "one of a kind." The game marked Lance's first appearance back at Levi's Stadium since his trade to the Chargers. The 49ers concluded their preseason with this win, prompting discussions about standout and disappointing players from the camp. Meanwhile, Lance is reportedly close to securing the backup quarterback position with the Chargers under Harbaugh.