On April 14, 2025, the iShares Biotechnology ETF ($XBI) led major indices, closing up 3.44%, marking it as the only index to reach new highs for the day. The ETF's performance was attributed to above-average trading volume and positive expectations for upcoming medical meetings. In contrast, the broader market showed limited movement among individual stocks, with the S&P 500 ETF ($SPY) also mentioned as part of the market activity. Analysts anticipate that many U.S. stocks will pull guidance, but biotechs are expected to either exceed or maintain their guidance amid ongoing economic uncertainty.