Artificial-intelligence start-up Abridge has raised $300 million in a Series E round led by Andreessen Horowitz, with participation from Khosla Ventures, lifting the company’s valuation to $5.3 billion. The deal nearly doubles the Pittsburgh-based firm’s worth just four months after it secured $250 million at a $2.75 billion valuation. Founded in 2018, Abridge uses generative AI to convert doctor-patient conversations into clinical notes that can be uploaded directly into electronic health records and billing systems. The company says its software is deployed across more than 150 U.S. health systems and is on pace to handle over 50 million medical encounters this year, a capability it argues can cut clinician paperwork and reduce burnout. Chief Executive Officer Shiv Rao said the fresh capital will fund hiring of machine-learning researchers and engineers and accelerate product development as competition intensifies in the ambient AI scribe market. The transaction ranks among the largest U.S. health-tech financings of 2025 and signals that venture investors remain eager to back generative-AI applications even as broader private-market fundraising slows.