The U.S. Federal Trade Commission (FTC), under new Chairman Andrew Ferguson, is advancing lawsuits, including some initiated during the Biden administration, which could impact U.S. businesses. This activity aligns with President Donald Trump's executive order promoting a deregulatory agenda focused on anticompetitive regulations, positioning the FTC at the center of this process. Concurrently, federal enforcement of the Foreign Corrupt Practices Act (FCPA) has been paused, prompting state Attorneys General in the U.S. to potentially increase their enforcement efforts against foreign anti-corruption violations. In the realm of intellectual property, the U.S. Patent and Trademark Office (USPTO) has reshaped its approach to discretionary denials in post-grant proceedings, introducing new pre-institution discretionary briefing procedures. Additionally, there are developments at the state level that could alter the landscape of U.S. criminal antitrust enforcement. These regulatory and enforcement trends are accompanied by ongoing discussions and guidance on Environmental, Social, and Governance (ESG) compliance, reflecting evolving global regulatory regimes.