The American College of Cardiology (ACC) has issued new guidance recommending that adults with cardiovascular disease receive vaccinations against five respiratory illnesses: COVID-19, influenza, respiratory syncytial virus (RSV), pneumococcal infection, and shingles. This recommendation follows research highlighting the substantial burden of RSV-related hospitalizations among older adults in the United States, particularly those aged 60 and above, prior to the availability of an RSV vaccine. Additionally, infants younger than six months are reported to be at three times higher risk of hospitalization from severe RSV compared to human metapneumovirus (HMPV). In a related development, the American College of Obstetricians and Gynecologists (ACOG) has diverged from CDC guidance by recommending maternal vaccination against COVID-19, encouraging all pregnant women, those trying to conceive, and nursing mothers to receive an updated COVID-19 vaccine. These developments underscore a growing emphasis on vaccination to protect vulnerable populations from respiratory illnesses.