A recent randomized clinical trial conducted over eight weeks compared the effects of ultra-processed and minimally processed diets on weight loss while both diets adhered to national nutritional guidelines. The study involved 55 participants, primarily women with an average BMI of 33, who habitually consumed diets with approximately 67% ultra-processed foods. Results showed that participants lost weight on both diets; however, those on the minimally processed diet experienced twice the amount of weight and fat mass loss compared to those on the ultra-processed diet. Despite some previous studies suggesting ultra-processed foods may increase appetite and caloric intake, this trial found that participants on the ultra-processed diet ate less yet still lost less weight. The findings challenge industry claims about the healthfulness of ultra-processed foods and suggest that minimally processed meals may be more effective for weight loss and reducing cardiometabolic risk, even when ultra-processed foods meet healthy eating recommendations. The research was highlighted in publications such as Nature Medicine and received attention from multiple health and science outlets.