Long-awaited changes to research misconduct rules have been introduced by the ORI, addressing growing concerns about the integrity of scientific research. These new rules aim to help universities better investigate and manage claims of research misconduct. The changes come in response to the increasing number of misconduct claims and criticisms of previous guidelines, including the highly criticized NPRM. The updated regulations include thoughtful revisions and are expected to mitigate risks associated with decentralized clinical trials. Experts believe these changes could significantly improve the oversight and accountability of research practices in the health sector.