The U.S. Department of Justice (DOJ) has outlined new priorities and initiatives in its antitrust and white-collar enforcement efforts. DOJ antitrust leadership is focusing on procedural fairness and targeted enforcement in merger reviews, signaling a refined approach to scrutinizing corporate consolidations. Concurrently, the DOJ has elevated customs fraud to a major enforcement priority within its white-collar crime agenda, highlighting increased risks in this area. Additionally, the DOJ announced a new initiative to combat civil rights fraud through the False Claims Act, reflecting an expansion of its enforcement scope. The Federal Trade Commission (FTC) and DOJ have also approved structural remedies for two significant technology mergers, indicating a willingness to allow consolidation under certain conditions. Meanwhile, changes to the Hart-Scott-Rodino (HSR) rules have been introduced, altering the landscape for merger filings and requiring attention from general counsels and dealmakers. The ongoing HPE-Juniper merger trial is noted as a potential challenge to the DOJ's enforcement capabilities against monopolies. Furthermore, updated Foreign Corrupt Practices Act (FCPA) guidance has been issued, emphasizing compliance and enforcement in corporate conduct. These developments collectively demonstrate a strategic shift in the DOJ’s enforcement posture under the current administration, balancing rigorous oversight with procedural fairness and targeted interventions.