The S&P 500 saw notable stock performance divergences in 2024. Walgreens Boots Alliance emerged as the worst-performing stock, declining 64.3% due to an unsuccessful global healthcare strategy and intense competition. Intel followed, falling 60.1% as it struggled to adapt to industry changes, including competition from Taiwan Semiconductor and the rise of AI. Moderna, which saw a 58.2% drop, faced challenges as demand for its COVID-19 vaccine waned. Other significant losers included Celanese, down 55.5% amid global economic weakness, and Estee Lauder, which declined 48.7% due to weak demand in key markets like China. On the positive side, AppLovin led gains with a 713% increase, driven by AI integration and strong revenue growth. Palantir and MicroStrategy also saw substantial gains, benefiting from AI advancements and Bitcoin's surge, respectively.