Short sellers focusing on U.S. companies with a market capitalization exceeding $1 billion have reported gains of $54.9 billion for the week ending Thursday, according to data from Ortex Technologies. This increase contributes to total short sellers' profits for the year, which have reached $118.5 billion as of the same date. The data highlights a growing trend in short selling amid market fluctuations, particularly affecting major indices such as the Nasdaq-100 and S&P 500, represented by ETFs like QQQ and SPY.