A federal grand jury on Friday indicted New Orleans Mayor LaToya Cantrell on corruption-related charges, capping a multiyear investigation and making her the first sitting mayor in the city’s 307-year history to face federal criminal prosecution. The indictment, announced by the U.S. Justice Department, also names former New Orleans Police Department officer Jeffrey Vappie, who previously served on Cantrell’s security detail. Court documents, expected to be unsealed in the coming days, are widely anticipated to outline allegations of bribery, misuse of city resources and other misconduct examined by FBI agents during the probe. Cantrell, 53, a Democrat first elected in 2018 and re-elected in 2022, has denied wrongdoing. Her office did not immediately respond to requests for comment. An initial appearance in U.S. District Court for the Eastern District of Louisiana could come as early as next week. The case extends a recent series of public-corruption prosecutions pursued by the Trump administration, which has pledged tougher enforcement against local-government misconduct. Potential penalties for Cantrell and Vappie will depend on the precise charges detailed when the indictment is formally unsealed.