Several organizations and industry participants have recently engaged with U.S. regulatory bodies regarding the oversight of decentralized finance (DeFi) and perpetual derivatives markets. Talos submitted a comment letter to the Commodity Futures Trading Commission (CFTC) highlighting insights on perpetual derivatives, authored by Josh Peschko. Paradigm urged the CFTC to establish a regulatory framework for DeFi perpetual derivatives, emphasizing that current regulations focused on centralized exchanges overlook the transformative potential of DeFi. Paradigm also proposed the creation of a new advisory committee composed of experts to guide this framework. Additionally, the Digital Chamber submitted two comment letters to the CFTC addressing the regulatory treatment of perpetual derivatives and the feasibility of 24/7 trading and clearing in CFTC-regulated markets. On the Securities and Exchange Commission (SEC) side, the DeFi Education Fund (DEF) and Uniswap Foundation sent a letter to the SEC Crypto Task Force recommending principles specifically for decentralized autonomous organizations (DAOs). The SEC plans to hold a crypto roundtable on June 9 to discuss DeFi regulation and autonomy, with a panel regarded as critical by industry observers. These developments reflect ongoing dialogue between regulators and the crypto industry aimed at shaping the regulatory landscape for DeFi and related financial instruments.