The San Francisco 49ers featured several key players in their preseason game against the Las Vegas Raiders on August 16, 2025, with quarterback Brock Purdy starting and performing well. Purdy completed 5 of 7 passes for 66 yards on the opening drive, contributing to a 49ers field goal. Backup quarterbacks Mac Jones and Carter Bradley also saw playing time, with Jones completing 13 of 16 passes for 135 yards but throwing an interception. The 49ers secured a preseason win over the Raiders, with standout performances from offensive players Brock Purdy, Demarcus Robinson, Ricky Pearsall, and Robbie Chosen, according to Pro Football Focus (PFF) grades. On defense, Jaylen Mahoney and Chase Lucas were among the top-graded players. Following the game, the 49ers signed veteran quarterback Nate Sudfeld, who previously played for the team in 2021, to compete for the No. 3 quarterback position. This move coincided with injuries to running back Patrick Taylor Jr., who was placed on season-ending injured reserve due to a shoulder injury requiring surgery, and backup quarterback Mac Jones, who suffered a knee injury and missed subsequent practices. The team also saw the return of several players to practice, including Nick Bosa and Isaac Guerendo. Head coach Kyle Shanahan described rookie running back Corey Kiner's high ankle sprain as "pretty bad," and the team is preparing for roster cutdowns with some players designated to return from injured reserve.