The San Francisco 49ers face significant challenges at the wide receiver position ahead of the 2025 NFL season due to injuries and suspensions affecting key players including Jauan Jennings, Jacob Cowing, Brandon Aiyuk, and Jordan Watkins. Jennings and Cowing's availability for Week 1 remains uncertain, with Cowing expected to miss six weeks due to a grade 2 hamstring strain and likely starting on the Physically Unable to Perform (PUP) list. Russell Gage is anticipated to return within a 7-10 day window, while Watkins may be sidelined for approximately one month. In response to these setbacks, the 49ers have made a trade with the Kansas City Chiefs to bolster their wide receiver corps. The team will need at least five wide receivers available by Week 1, including Ricky Pearsall, Russell Gage, and Skyy Moore, with Jennings, Cowing, Robbie Chosen, and Isaiah Hodgins competing for remaining spots. Preseason performances highlighted several standout players: on defense, Luke Gifford, Trevis Gipson, and Siran Neal received the highest Pro Football Focus (PFF) grades among those playing at least 30 snaps, while offensive leaders included Demarcus Robinson, Drew Moss, and Corey Kiner. Defensive line pressures in the preseason finale against the Los Angeles Chargers were led by Robert Beal Jr. with five pressures, followed by Trevis Gipson with four. The 49ers are projected to carry nine or ten defensive linemen on their 53-man roster, with Sebastian Valdez and Robert Beal Jr. as potential additions. Kevin Givens and Jacob Cowing are considered the most likely candidates for return-from-injury designations. The team’s preseason concluded with a win over the Chargers, setting the stage for roster decisions ahead of the regular season.