Recent research developments in neuroscience have highlighted several advances in understanding brain function and neurological disorders. A notable discovery by the Eisenberg lab, published in Nature, identified a short peptide capable of breaking up Tau fibrils, which are implicated in Alzheimer's disease, addressing a critical gap as no approved therapies currently target these fibrils directly. Additional studies have explored various neural mechanisms, including the role of perisomatic inhibition and ripples in hippocampal development, neural activity during speech production, and the encoding of valence by the anterior cingulate cortex in mice. Research into autism spectrum disorder revealed alterations in anterior cingulate folding patterns and peripheral transcriptomic responses to music. Other findings include the modulation of threat detection by norepinephrine acting through radial astrocytes, the degeneration of parvalbumin neurons linked to microglial loss of FMRP, and the impact of chronic alcohol exposure on inhibitory synapse remodeling in striatal interneurons. Advances in neuroimaging and machine learning have facilitated better prediction of antidepressant treatment responses and the study of cognitive effort allocation. These studies collectively deepen the understanding of neural circuits, neurodegenerative diseases, and potential therapeutic targets.
Perineuronal Net and Inhibitory Synapse Remodeling on Striatal Fast-spiking Interneurons by Chronic Alcohol Exposure https://t.co/wAlrgmIY2O #biorxiv_neursci
Spatially resolved mapping of monoacylglycerol lipase activity in the brain https://t.co/sRE8mV7v9M #biorxiv_neursci
The Functional Epididymal Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain ... https://t.co/2tpS6T1s03 #biorxiv_neursci