Colorado Buffaloes head football coach Deion Sanders disclosed at a press conference on July 28, 2025, that he had been diagnosed with an aggressive cancerous tumor on his bladder during the offseason. Sanders underwent surgery to have his bladder removed and is now cancer-free. He lost 25 pounds following the procedure but confirmed he will return to coach Colorado for a third season. Earlier in July, during the Big 12 Media Days, Sanders declined to discuss his health, instead focusing on team matters and commenting on college football issues such as the NIL (Name, Image, Likeness) revenue-sharing era. He expressed support for Texas Tech coach Joey McGuire's spending on players and advocated for the introduction of a salary cap in college football. Sanders also made clear his intent to concentrate on coaching and the team rather than his personal health during media interactions in early July.