The San Francisco 49ers secured a 22-19 victory over the Las Vegas Raiders in their 2025 NFL preseason game. Quarterback Brock Purdy, expected to start and serving as the 49ers' official franchise QB, made his first preseason appearance, completing 5 of 7 passes for 66 yards on the opening drive that resulted in a field goal. Backup quarterback Mac Jones also saw significant action, completing 13 of 16 passes for 135 yards but throwing an interception. Carter Bradley replaced Purdy in the fourth quarter. Key offensive players Brock Purdy, George Kittle, Deommodore Lenoir, and Kyle Juszczyk participated in the game, while notable starters Christian McCaffrey, Brandon Aiyuk, Trent Williams, Nick Bosa, and Fred Warner did not play. The 49ers' offensive line faced challenges as starting right guard Dominick Puni was ruled out with a knee injury, later specified as a possible posterior-cruciate ligament injury expected to sideline him for several weeks. Rookie running back Corey Kiner, an undrafted free agent, also suffered a high ankle injury and was carted off the field, further impacting the team's depth at running back. The 49ers may consider shifting Spencer Burford back to guard to address the injury to Puni. Defensive standouts included Jaylen Mahoney and Chase Lucas, with Lucas continuing to demonstrate strong performance. On offense, besides Purdy, Demarcus Robinson, Ricky Pearsall, and Robbie Chosen received high grades from Pro Football Focus for their performances against the Raiders. The team continues to manage injuries as they approach the final week of the preseason and the upcoming roster cuts.