Renata Zarazúa produced the first major upset of the 2025 US Open, eliminating No. 6 seed and reigning Australian Open champion Madison Keys 6-7(10), 7-6(3), 7-5 in a three-hour first-round battle at Flushing Meadows. The 28-year-old Mexican, the only player from her country ranked inside the top 100, trailed by a set and 3-0 before rallying to claim her maiden victory over a top-10 opponent. According to tournament statisticians, Keys is only the second American woman seeded in the top 10 to fall in the opening round in New York over the past three decades. The day’s surprises had begun earlier when Czech veteran Barbora Krejcikova dispatched No. 22 seed Victoria Mboko of Canada 6-3, 6-2. Mboko, 18, was appearing in her first US Open main draw after winning the National Bank Open in Montreal this month but struggled with a taped right wrist and never threatened the two-time major champion. The early exits of Keys and Mboko remove two recent hard-court title-winners from the women’s bracket and widen the path for the tournament’s leading contenders as first-round play continues in New York.